CHL 5225 H -- ADVANCED STATISTICAL METHODS FOR CLINICAL TRIALS

Crossover Trials

Required Reading:

1. Woods JR, Williams JG, Tavel M. The two-period crossover design in medical research. Annals of Internal Medicine 1989; 110(7): 560-566. Download
2. Brown BW Jr. The cross-over experiment for clinical trials. Biometrics 1980; 36(1): 69-79. Download
3. Willan AR. Using the maximum test statistic in the two period crossover clinical trial. Biometrics 1988; 44: 211-218. Download
4. Mills EJ et al. Design, analysis, and presentation of crossover trials. Trials 2009; 10: 27. Download

References:

1. Piantadosi S. Clinical Trials: A Methodologic Perspective 1997; New York: John Wiley & Sons: Chapter 16.
2. Jones B, Kenward MG. (1989) Design and Analysis of Cross-over Trials 1989; London: Chapman and Hall: Chapters 1, 2 & 3.
3. Senn S. Cross-over Trials in Clinical Research 1983; New York: John Wiley & Sons: Chapters 1, 2, 3 & 4.
4. Willan AR, Pater J. Carryover and the two-period crossover clinical trial. Biometrics 1986; 42: 593-599.
5. Willan AR, Pater J. Using baseline measurements in the two-period crossover trial. Controlled Clinical Trials 1986; 7: 282-289
6. Rietbergen C, Moerbeek M. The design of cluster randomized crossover trials. J. of Educ. and Behav. Statistics 2011; 36(4): 472-490
7. Giraudeau B. Ravaud P, Donner A. Sample size calculation for cluster randomized cross-over trials. Statist. Med. 2008; 27(27): 5578–5585

Class Notes

Assignment